Publiée 2 juillet 2026
POSTDOC_036_IS - H/F
Inserm
Illkirch-Graffenstaden, Grand-Est 67400, France
CDI
POSTDOC_036_IS - H/F
Illkirch-Graffenstaden
L'entreprise
L'Inserm est le seul organisme public français entièrement dédié à la recherche biologique, médicale et en santé des populations. Il dispose de laboratoires de recherche sur l'ensemble du territoire, regroupés en 12 Délégations Régionales. Notre institut réunit 15 000 chercheurs, ingénieurs, techniciens et personnels administratifs, avec un objectif commun : améliorer la santé de tous par le progrès des connaissances sur le vivant et sur les maladies, l'innovation dans les traitements et la recherche en santé publique.
Rejoindre l'Inserm, c'est intégrer un institut engagé pour la parité et l'égalité professionnelle, la diversité et l'accompagnement de ses agents en situation de handicap, dès le recrutement et tout au long de la carrière. Afin de préserver le bien-être au travail, l'Inserm mène une politique active en matière de conditions de travail, reposant notamment sur un juste équilibre entre vie personnelle et vie professionnelle.
L'Inserm a reçu en 2016 le label européen HR Excellence in Research et s'est engagé à faire évoluer ses pratiques de recrutement et d'évaluation des chercheurs.
À propos du poste
The successful candidate will join the team within the Functional Genomics and Cancer Department at IGBMC, which investigates the signaling pathways responsible for the assembly of nuclear pore complexes during the cell cycle in both healthy and diseased cells. They will work under the direct supervision of the team leader, Izabela Sumara.
The successful candidate will investigate the mechanisms governing nuclear pore complex (NPC) assembly in healthy and diseased cells.
Scientific project and responsibilities :
Asymmetric arginine dimethylation (ADMA) is a key post-translational modification involved in the regulation of chromatin organization, RNA processing, and gene expression. Nuclear pore complexes (NPCs) are large protein assemblies embedded in the nuclear envelope (NE) that mediate bidirectional transport between the nucleus and the cytoplasm. In addition, NPCs establish direct interactions with chromatin and contribute to gene regulation. Despite their nuclear localization and function, it remains unknown whether ADMA directly or indirectly influences NPC assembly. Our preliminary findings demonstrate a critical role for ADMA in the proper localization of nucleoporins (Nups), the building blocks of NPCs, and in the correct assembly of NPCs at the nuclear envelope in human cells.
The successful candidate will investigate the precise molecular mechanisms by which ADMA regulates NPC assembly in healthy and cancer cells by combining cell biology, advanced microscopy, and biochemical approaches.
The successful candidate will actively communicate their research findings within the laboratory and the institute.
The successful candidate will supervise Master's students.
Profil recherché
The successful candidate must hold a PhD in Biology and have experience in molecular and cell biology, cell culture, and microscopy.
The successful candidate should demonstrate strong scientific expertise, scientific rigor, excellent organizational skills, and proficiency in English (minimum C1 level according to the Common European Framework of Reference for Languages).
The successful candidate should be dynamic, respectful, highly motivated, and possess excellent teamwork skills.
Éléments nécessaires pour postuler
Document(s)
Curriculum VitæLettre de motivation
Illkirch-Graffenstaden
L'entreprise
L'Inserm est le seul organisme public français entièrement dédié à la recherche biologique, médicale et en santé des populations. Il dispose de laboratoires de recherche sur l'ensemble du territoire, regroupés en 12 Délégations Régionales. Notre institut réunit 15 000 chercheurs, ingénieurs, techniciens et personnels administratifs, avec un objectif commun : améliorer la santé de tous par le progrès des connaissances sur le vivant et sur les maladies, l'innovation dans les traitements et la recherche en santé publique.
Rejoindre l'Inserm, c'est intégrer un institut engagé pour la parité et l'égalité professionnelle, la diversité et l'accompagnement de ses agents en situation de handicap, dès le recrutement et tout au long de la carrière. Afin de préserver le bien-être au travail, l'Inserm mène une politique active en matière de conditions de travail, reposant notamment sur un juste équilibre entre vie personnelle et vie professionnelle.
L'Inserm a reçu en 2016 le label européen HR Excellence in Research et s'est engagé à faire évoluer ses pratiques de recrutement et d'évaluation des chercheurs.
À propos du poste
The successful candidate will join the team within the Functional Genomics and Cancer Department at IGBMC, which investigates the signaling pathways responsible for the assembly of nuclear pore complexes during the cell cycle in both healthy and diseased cells. They will work under the direct supervision of the team leader, Izabela Sumara.
The successful candidate will investigate the mechanisms governing nuclear pore complex (NPC) assembly in healthy and diseased cells.
Scientific project and responsibilities :
Asymmetric arginine dimethylation (ADMA) is a key post-translational modification involved in the regulation of chromatin organization, RNA processing, and gene expression. Nuclear pore complexes (NPCs) are large protein assemblies embedded in the nuclear envelope (NE) that mediate bidirectional transport between the nucleus and the cytoplasm. In addition, NPCs establish direct interactions with chromatin and contribute to gene regulation. Despite their nuclear localization and function, it remains unknown whether ADMA directly or indirectly influences NPC assembly. Our preliminary findings demonstrate a critical role for ADMA in the proper localization of nucleoporins (Nups), the building blocks of NPCs, and in the correct assembly of NPCs at the nuclear envelope in human cells.
The successful candidate will investigate the precise molecular mechanisms by which ADMA regulates NPC assembly in healthy and cancer cells by combining cell biology, advanced microscopy, and biochemical approaches.
The successful candidate will actively communicate their research findings within the laboratory and the institute.
The successful candidate will supervise Master's students.
Profil recherché
The successful candidate must hold a PhD in Biology and have experience in molecular and cell biology, cell culture, and microscopy.
The successful candidate should demonstrate strong scientific expertise, scientific rigor, excellent organizational skills, and proficiency in English (minimum C1 level according to the Common European Framework of Reference for Languages).
The successful candidate should be dynamic, respectful, highly motivated, and possess excellent teamwork skills.
Éléments nécessaires pour postuler
Document(s)
Curriculum VitæLettre de motivation
