Publiée 25 juillet 2026
DOCTORANT_052_RP - H/F
Inserm
Illkirch-Graffenstaden, Grand-Est 67400, France
CDI
DOCTORANT_052_RP - H/F
Illkirch-Graffenstaden
L'entreprise
L'Inserm est le seul organisme public français entièrement dédié à la recherche biologique, médicale et en santé des populations. Il dispose de laboratoires de recherche sur l'ensemble du territoire, regroupés en 12 Délégations Régionales. Notre institut réunit 15 000 chercheurs, ingénieurs, techniciens et personnels administratifs, avec un objectif commun : améliorer la santé de tous par le progrès des connaissances sur le vivant et sur les maladies, l'innovation dans les traitements et la recherche en santé publique.
Rejoindre l'Inserm, c'est intégrer un institut engagé pour la parité et l'égalité professionnelle, la diversité et l'accompagnement de ses agents en situation de handicap, dès le recrutement et tout au long de la carrière. Afin de préserver le bien-être au travail, l'Inserm mène une politique active en matière de conditions de travail, reposant notamment sur un juste équilibre entre vie personnelle et vie professionnelle.
L'Inserm a reçu en 2016 le label européen HR Excellence in Research et s'est engagé à faire évoluer ses pratiques de recrutement et d'évaluation des chercheurs.
À propos du poste
We are seeking a highly motivated and enthusiastic individual to join our research group at IGBMC. Our overall aim is to better understand how cellular identity is determined at the molecular level, using embryonic stem cells as a model system. We combine genetic engineering, genomics, biochemical and cellular assays to dissect the function of important transcriptional and epigenetic regulators both in physiological and pathological conditions.
Profil recherché
We are seeking a highly motivated and enthusiastic individual to join our research group at IGBMC. Our overall aim is to better understand how cellular identity is determined at the molecular level, using embryonic stem cells as a model system. We combine genetic engineering, genomics, biochemical and cellular assays to dissect the function of important transcriptional and epigenetic regulators both in physiological and pathological conditions.
In this PhD project, you will exploit state-of-the-art genomics techniques to dissect the molecular function of the transcription factor SALL4 in embryonic stem cells: regulation of transcription via long range enhancer-promoter looping (1), regulation of 3D genome structure via modulation of lamina-associated domains (2). These investigations will help us better understand how SALL4 controls embryonic development, and how this protein is de-regulated in developmental disorders and aggressive cancers. More generally, this work will clarify how transcription factors interact across different genomic scales to regulate cell identity. Additional information regarding the PhD project is available here: https://amethis3.unistra.fr/amethis-client/prd/consulter/offre/1125
You will benefit from a supportive and collaborative work environment to carry out your research. The Institute of Genetics Molecular and Cellular Biology (IGBMC) includes a diverse and international scientific community and hosts a large range of state-of-the-art facilities including genomics, bioinformatics, proteomics, microscopy, flow cytometry and cell culture.
Relevant publications:
1- Chhatbar et al., bioRxiv (2025): https://doi.org/10.1101/2025.11.14.688441
2- Giuliani et al., bioRxiv (2025): https://doi.org/10.1101/2025.10.27.684836
3- Pantier et al., Mol Cell (2021): https://doi.org/10.1016/j.molcel.2020.11.046
Keywords: stem cells, transcription, genome architecture, transcription factors, SALL4, CRISPR/Cas9 engineering, next-generation sequencing
Qualifications and requirements
- Recently obtained Master degree in genomics, molecular biology or other relevant discipline.
- Strong motivation to work in the field of gene regulation and chromatin biology.
- Good handling of standard molecular biology techniques.
- Prior experience in generating or analysing genomics data would be desirable, but not mandatory.
- English language proficiency (B2 or higher).
Éléments nécessaires pour postuler
Document(s)
Curriculum VitæLettre de motivationRéférences
Illkirch-Graffenstaden
L'entreprise
L'Inserm est le seul organisme public français entièrement dédié à la recherche biologique, médicale et en santé des populations. Il dispose de laboratoires de recherche sur l'ensemble du territoire, regroupés en 12 Délégations Régionales. Notre institut réunit 15 000 chercheurs, ingénieurs, techniciens et personnels administratifs, avec un objectif commun : améliorer la santé de tous par le progrès des connaissances sur le vivant et sur les maladies, l'innovation dans les traitements et la recherche en santé publique.
Rejoindre l'Inserm, c'est intégrer un institut engagé pour la parité et l'égalité professionnelle, la diversité et l'accompagnement de ses agents en situation de handicap, dès le recrutement et tout au long de la carrière. Afin de préserver le bien-être au travail, l'Inserm mène une politique active en matière de conditions de travail, reposant notamment sur un juste équilibre entre vie personnelle et vie professionnelle.
L'Inserm a reçu en 2016 le label européen HR Excellence in Research et s'est engagé à faire évoluer ses pratiques de recrutement et d'évaluation des chercheurs.
À propos du poste
We are seeking a highly motivated and enthusiastic individual to join our research group at IGBMC. Our overall aim is to better understand how cellular identity is determined at the molecular level, using embryonic stem cells as a model system. We combine genetic engineering, genomics, biochemical and cellular assays to dissect the function of important transcriptional and epigenetic regulators both in physiological and pathological conditions.
Profil recherché
We are seeking a highly motivated and enthusiastic individual to join our research group at IGBMC. Our overall aim is to better understand how cellular identity is determined at the molecular level, using embryonic stem cells as a model system. We combine genetic engineering, genomics, biochemical and cellular assays to dissect the function of important transcriptional and epigenetic regulators both in physiological and pathological conditions.
In this PhD project, you will exploit state-of-the-art genomics techniques to dissect the molecular function of the transcription factor SALL4 in embryonic stem cells: regulation of transcription via long range enhancer-promoter looping (1), regulation of 3D genome structure via modulation of lamina-associated domains (2). These investigations will help us better understand how SALL4 controls embryonic development, and how this protein is de-regulated in developmental disorders and aggressive cancers. More generally, this work will clarify how transcription factors interact across different genomic scales to regulate cell identity. Additional information regarding the PhD project is available here: https://amethis3.unistra.fr/amethis-client/prd/consulter/offre/1125
You will benefit from a supportive and collaborative work environment to carry out your research. The Institute of Genetics Molecular and Cellular Biology (IGBMC) includes a diverse and international scientific community and hosts a large range of state-of-the-art facilities including genomics, bioinformatics, proteomics, microscopy, flow cytometry and cell culture.
Relevant publications:
1- Chhatbar et al., bioRxiv (2025): https://doi.org/10.1101/2025.11.14.688441
2- Giuliani et al., bioRxiv (2025): https://doi.org/10.1101/2025.10.27.684836
3- Pantier et al., Mol Cell (2021): https://doi.org/10.1016/j.molcel.2020.11.046
Keywords: stem cells, transcription, genome architecture, transcription factors, SALL4, CRISPR/Cas9 engineering, next-generation sequencing
Qualifications and requirements
- Recently obtained Master degree in genomics, molecular biology or other relevant discipline.
- Strong motivation to work in the field of gene regulation and chromatin biology.
- Good handling of standard molecular biology techniques.
- Prior experience in generating or analysing genomics data would be desirable, but not mandatory.
- English language proficiency (B2 or higher).
Éléments nécessaires pour postuler
Document(s)
Curriculum VitæLettre de motivationRéférences
